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High Sugar Foods Both sugary beverages and sugary snacks should be avoided for optimal GLP-1 levels

That PKA and Epac each play critical roles in GLP-1-mediated insulin release is evidenced by the ability of Epac or PKA specific activators (or inhibitors) to potentiate (or inhibit) glucose-dependent insulin secretion [6972]

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According to Ferraz-Bannitz, previous in vitro studies had already shown that serotonin is able to stimulate the secretion of insulin in pancreatic beta cells and GLP-1 in intestinal neuroendocrine cells