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GLP-1 medications work through two primary mechanisms within the brain: Strengthening the blood-brain barrier, which protects against harmful substances 28 Reducing neuroinflammation through specialized brain cells called microglia and astrocytes 29 GLP-1 receptor signaling enhances neuron growth and survival 28

Others need higher doses

Zepbound (tirzepatide) is an FDA approved weight loss medication that targets both GLP-1 and GIP receptors