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Na V 1.8 was detected in a subset of postganglionic neurons in thoracic sympathetic ganglia in humans and mice, where p.R14L produced a gain-of-function profile that enhanced cholinergic responsiveness

Racial and ethnic minorities carry a disproportionate burden of obesity and T2D in the general population, but their enrolment in the completed tirzepatide trials was lower than expected, which raises concerns regarding the generalizability of these trials

Hallucinations are more common among children and the elderly than adults

Moreover, incorporating unnatural amino acids can reduce peptide drugs immunogenicity, as the human immune system primarily recognizes peptide segments composed of L-amino acids