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The factors that favor staying at 8mg include: already excellent weight loss trajectory, minimal side effects at 8mg that you prefer to maintain, sensitivity to GI side effects that worsened with previous dose increases, and achievement of target weight at the 8mg rate

Sleep deprivation can increase levels of ghrelin (the hunger hormone) and decrease leptin (the fullness hormone), which can work against the benefits of your weight loss program

Red flags that warrant immediate medical attention include suicidal thoughts, severe mood changes within days of starting or increasing the dose, withdrawal from social activities, or loss of interest in activities you normally enjoy

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Song Y, Klevak A, Manson JE, Buring JE, Liu S