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Most patients notice cold sensitivity peak during the first 48 weeks of treatment, then gradually improve as their body adapts

Some protocols involve continuous administration for 6-12 months with periodic assessment and dose adjustment

Supriya Rao, MD, gastroenterologist and managing partner at Integrated Gastroenterology Consultants, estimates that her patients require some type of prior authorization around 50% of the time, and insurance companies require them to try a different drug first, roughly a quarter of the time

Long-term studies show maintained weight loss with ongoing GLP-1 therapy over two years and beyond