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Studies have found that GLP-1 promotes neural stem cell proliferation and differentiation, increasing dopaminergic neuron generation by activating PI3K/Akt and MAPK/ERK signaling pathways

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Moreover, there is a need for additional studies that identify patients or sub-types of patients with various addictions who might benefit from treatment with such medications: for instance, the possibility that polymorphisms in the GLP-1R genes influence the treatment outcome of GLP-1R agonists on alcohol drinking in patients with AUD

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