review on glp-1 agonists and psychiatric effects Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] Frontiers | GLP-1 Receptor Agonists:

They burn triglycerides into free fatty acids that are oxidized to generate heat

34 , 35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36 , 37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38 , 39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals

This rapid increase in users of GLP-1 drugs has caused worldwide shortages of these medications for people with type 2 diabetes who need them

If you maintain or improve the circulatory system, you can also help organ function, he says