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Wegovy EPAR public assessment report

A good GLP-1 should: Fit your weekly or daily schedule Cause manageable side effects

Vomiting is 17% versus 24%

Headline results from ESSENCE, which formed the basis of that 2025 approval, included: About 63 percent of semaglutide-treated patients reached resolution of steatohepatitis without worsening of liver fibrosis at 72 weeks Approximately 37 percent showed measurable improvement in liver fibrosis (the scarring that drives long-term liver damage) Mean body-weight reduction reached roughly 10 percent over 72 weeks of weekly subcutaneous semaglutide Gastrointestinal symptoms (nausea, early fullness, mild diarrhea) were the most common side effects, generally manageable with gradual dose escalation Source: FDA Wegovy approval materials, 2025 (FDA Drugs) The SLIM LIVER Trial and What It Found in People with HIV The ESSENCE numbers above come from the general MASH population, not specifically from people living with HIV