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Baseline thyroid function tests, including TSH and free T4, should be documented before initiating treatment, with the patient ideally in a euthyroid state on stable levothyroxine replacement

Activation of NTS GLP-1R neurons induced nonaversive satiety, likely via projections to the PVH, and this circuit was preferentially activated by nutrients rather than non-nutritive aversive stimuli (123)
GLP-1(2836) does not bind sAC, but binds MTP in mouse whole-heart lysates
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