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doi: 10.1111/dom.14725 45 CrinAGrugniG
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UKPDS (UK Prospective Diabetes Study), a large randomized clinical study in the newly diagnosed T2D population found significant as well as persistent risk reduction in myocardial infarction (33%, p = 0.005), death from any cause (27%, p = 0.002) and diabetes-related endpoint (21%, p = 0.01) in metformin-treated individuals
