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As the disease progresses, clinical manifestations may emerge, including, but not limited to, refractory hypertension, peripheral or generalized edema, glaucoma, proteinuria characterized by foamy urine, and a range of systemic complications, such as cardiac, neurological and respiratory disorders [23,24,25,26]

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Regarding the mechanism by which GLP-1RAs are taken up into the brain, it has been reported that GLP-1RAs do not cross the blood-brain barrier through endothelial cells [5]

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