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This increases the expression of alpha-smooth muscle actin (-SMA) and vascular cell adhesion molecule-1 (VCAM-1), which are effective in fibrous formation

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In the EAE model, activated macrophages, monocytes, dendritic cells, as well as apoptotic oligodendrocytes release pathogen-associated molecular pattern or DAMP, like the high mobility group box protein-1 to the extracellular environment, and initiate an inflammatory response characterized by the activation of the inflammasome (Barclay and Shinohara, 2017