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The structure enables a comparison of the only two inactive peptide-free class B GPCR structures and increases our structural understanding of their activation pathways, which may be helpful in the design of novel ligands, thereby enabling new avenues for drug discovery on therapeutically important class B GPCRs

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Search strategy We used the following search strategy: (irritable bowel syndrome OR IBS OR spastic colon OR irritable colon) AND (Glucagon like peptide 1 receptor agonist OR GLP-1 agonist OR Semaglutide OR Dulaglutide OR Exenatide OR Liraglutide OR Lixisenatide OR Tirzepatide)