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However, their effects on bone integrity remain complex, with some evidence indicating bone-protective mechanisms while others suggest potential increases in bone resorption associated with weight loss
In this capacity ADA functions as a costimulatory signal that potentiates T cell activation and induces the production of the T-helper cell (Th1) pro-inflammatory cytokines
It is also associated with cardiovascular benefits due to its lipid-lowering and anti-inflammatory effects
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