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Semaglutide can help our patients reach a healthy weight

Effectiveness A 2023 JAMA Network study found that participants using tirzepatide lost an average of 25% of body fat within the first yearcompared to about 15% for semaglutide users

Unlike traditional weight loss medications that primarily target a single pathway, Zepbound works by activating both the GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors

Tissue distribution of GLP-1R GLP-1 mediates its effects by binding to its receptor, the GLP-1R, which is a sevenfold transmembrane G-coupled receptor that increases levels of cAMP by activating adenylate cyclase (89, 95, 96)