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Abbreviations CAD: Coronary artery disease EAT: Epicardial adipose tissue HF: Heart failure SGLT2i: Sodium-glucose cotransporter-2 inhibitors T2DM: Type 2 diabetes CV: Cardiovascular MACE: Major adverse cardiovascular events SAT: Subcutaneous adipose tissue CFR: Coronary flow reserve WAT: White adipose tissue BAT: Brown adipose tissue UCP 1: Uncoupling protein 1 FGF-21: Fibroblast growth factor 21 PCOS: Polycystic ovary syndrome SOD2: Enzyme superoxide dismutase PRDM16: PR domain-containing 16 FFAs: Free fatty acids IL-6: Interleukin-6 TNF-r1: Tumor necrosis factor receptor-1 TNF-: Tumor necrosis factor- PAI-1: Plasminogen activator inhibitor-1 References Zinman B, et al

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8 Moreover, the routine exclusion of individuals with significant psychiatric comorbidities from GLP1RA clinical trials limits the generalisability of findings and perpetuates an evidence gap for highrisk populations

In 2024, 95% of adverse events associated with GLP-1s were related to either how the product was dosed or how it was administered, rather than issues with the drug