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While the score correlated with who was likely to lose weight on semaglutide, nongenetic factors also played a big role, Cirulli says

The sharp spike of dopamine that usually follows a drink or a gambling win doesnt happen when youre taking these medications

The literature falls into four tiers

Many people notice early changes within a few weeks, such as reduced appetite and improved portion control, as described in this week-by-week guide
