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Twostepcismr: A novel method and R package for attenuating bias in cis-mendelian randomization analyses

Although preliminary studies across various metabolic and mental disorders flank these promising findings regarding potential treatments of motivational dysfunction, we also highlight the need to investigate reward phases beyond anticipation to fully capitalize on the potential of gut-based interventions, specifically for mental disorders

These alternatives may appeal to patients seeking affordability or access during shortages, although they operate in a regulatory gray zone that is drawing increasing scrutiny from the FDA

PMID 27059958