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RPE-derived insulin appears to be stimulated by photoreceptor outer segment phagocytosis and may act through autocrine and paracrine mechanisms to maintain retinal function and support glucose uptake, lipid metabolism, and neurovascular integrity, even under systemic insulin deficiency, opening new therapeutic perspectives for preserving vision

Interestingly, reproductive responses were partially different in the PCOS model of preserved ovulation, since treatment of PNA mice with a low dose of GLP1/E was capable to elevate LH levels and reversed, to a large extent, the ovarian cycle irregularities observed in PNA mice treated with vehicle
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