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The activation of Wnt/-catenin pathway can promote the proliferation and differentiation of mesenchymal stem cells and osteoblasts, increase cell activity and promote osteogenic differentiation (Deng et al., 2019

However, other types of cancer occurred at a similar level between patients who took sitagliptin and those with other therapies (90)

Abbreviations T2D: Type 2 diabetes SA: Sleep apnea GLP-1RAs: Glucagon-like peptide-1 receptor agonists LDSC: Linkage disequilibrium score regression MR: Mendelian Randomization IVW: Inverse-variance weighted GWAS: Genome-wide association study eQTL: Expression quantitative trait loci SNP: Single nucleotide polymorphism HbA1c: Glycated hemoglobin A1c OSA: Obstructive sleep apnea CSA: Central sleep apnea AHI: Apneahypopnea index NAFLD: Non-alcoholic fatty liver disease RCT: Randomized controlled trials IV: Instrumental variables References Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, et al

The maximum recommended dosage is 20 mcg once daily