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Due to risks for diminished therapeutic effects of oral birth control pills, the manufacturer of Bydureon (exenatide) recommends taking birth control at least one hour prior to exenatide

The effects of exendin-4 on reward were also diminished by pretreatment with the estrogen receptor--selective antagonist, suggesting that signaling via the estrogen receptor- specifically is necessary for GLP-1R analog's reward-reducing effects (40)

In vitro expression and analysis of the 826 human G protein-coupled receptors

On top of this, oral formulations do not require specific conditions of sterility and other precautions against possible particle contamination, which may also have cost implications