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For weight loss without diabetes , most insurance plans deny coverage even when doctors prescribe off-label

Visible improvements in thickness, volume, and growth rate typically appear between months 3 and 6

(I am a big advocate of spacing out doses for people who have reached their goal weight, OR who are taking GLP-1s primarily for a possible metabolic/anti-inflammatory benefit, and who want to keep their weight neutral.) But maintenance dosing after achieving a clinical response is a completely different concept from starting at a sub-therapeutic dose and hoping it works

In agreement with the profound anti-inflammatory effects of GLP-1RAs, a recent study demonstrated a protective effect of these medications against the development of non-exudative AMD compared with other diabetes and lipid-lowering medications