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Functional mapping and expression data indicate the presence of GLP-1Rs in the central amygdala (CeA), hippocampus, and PFC, which are implicated in affective modulation of craving and top-down executive control [33]

Besides improving glucose control, reducing body weight, and lowering arterial blood pressure (surrogate endpoints), the breakthroughs were the demonstration of a significant reduction in cardiovascular and renal events in patients with type 2 diabetes at high risk

Other weight-loss drugs approved for long-term use, like naltrexone/bupropion (Contrave) and phentermine/topiramate (Qsymia), suppress your appetite in different ways, like targeting nerves in the brain

Did the study have limitations