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Nearly a quarter (15%) even admit to only taking a dose when they feel that the effects are wearing off, rather than following the clinically recommended weekly schedule

doi: 10.1016/j.febslet.2014.03.051

others show no effect 21 Allen, R.W

2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American college of cardiology/american heart association joint committee on clinical practice guidelines
