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Specifically, in patients with HFpEF, increased EAT thickness shows a direct relationship with serum levels inflammatory and myocardial injury markers [102], and is associated with increased biventricular filling pressures [92, 93], right- and left-sided ventricular-arterial uncoupling [102], and impaired exercise tolerance, highlighted by reduced peak oxygen consumption and estimated peripheral oxygen extraction at cardiopulmonary exercise testing [102]

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