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Retatrutide acetate has efficacy for mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively

Currently, the only weight-loss drugs FDA-approved for use in adolescents ages 12 and older are liraglutide (Saxenda), orlistat (Xenical, Alli), and phentermine-topiramate (Qsymia)

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For home use injections, providers often advise not exceeding a cumulative ~300 mg per week unless theres a specific indication