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Chin Med J (Engl) 2008;121:21342138
Semaglutide and Direct GLP-1 Regulation of Appetite in the Brain Widely distributed in the brain CNS, GLP-1Rs display a crucial role in the regulation of hunger, satiety and feeding behavior to reduce energy intake [113,114]
S1A, GLP-1RA intervention was associated with a reduction in BMI when compared to metformin (MD = 1.11

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