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Some patients may notice increased fatigue during daily activities, which could be related to these body composition changes

Avoid Do not use Noveltreat in case of a history of Medullary Thyroid Carcinoma (cancer of the thyroid gland) or Multiple Endocrine Neoplasia Syndrome Type 2 (tumor of the endocrine gland) and Type 1 Diabetes

This triple receptor agonism distinguishes it from currently approved medicines such as semaglutide (GLP-1R only) and tirzepatide (GLP-1R and GIPR)

1065 With respect to pilots with DM, recent experience in Europe reported no episodes of pilot incapacitation nor worsening of glycemic control with insulin-treated DM