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In addition, AOPPs upregulate the Wnt/-catenin pathway through the receptor for advanced glycation end-products (RAGE) receptor, contributing to podocyte dysfunction [60]
In 2021, the International Diabetes Federation (IDF) reported that 537 million adults worldwide were living with diabetes, with this number predicted to rise to 643 million and 783 million by 2030 and 2045, respectively
Future research should also explore the effects of amylin-based combination therapy on body composition and preservation of lean mass, which remains a key unmet need in obesity pharmacotherapy

Heise T, De Vries JH, Coskun T, Urva S, Li J, Pratt EJ, Thomas MK, Mather KJ, Dunn JP, Haupt A, et al
