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Description
Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
SCFAs activate free fatty acid receptors FFAR2 and FFAR3 on L-cells, thereby stimulating GLP-1 secretion
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Based on these data, the main therapeutic strategy targeting GLP-1R has been development of agonists for the treatment of hyperglycemia
