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Science 2023;381:eabl7398.PubMed 63

Avoid or Use Acetaminophen with Caution If You: Have liver disease or damage Drink alcohol regularly or heavily Take blood thinners like warfarin Are you taking multiple medications that already contain acetaminophen Avoid or Use Ibuprofen with Caution If You: Have heart disease or a history of heart attack Have high blood pressure (hypertension) Have clotting or bleeding disorders Have kidney problems or reduced kidney function Are an older adult (higher risk of side effects) Are you pregnant or trying to conceive Are in the last 20 weeks of pregnancy (risk to the babys heart and kidneys) Are breastfeeding (consult a doctor before use) Have been advised to limit NSAIDs by your doctor Are at risk of stroke or cardiovascular complications Take medications that may interact with NSAIDs If you rely on pain relievers frequently, your body may be warning you