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The importance of these experiments is that that they show that it was not losing weight that helped a mouses bones and cartilage to recover

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Food intake regulation and signaling between the gut-adipose-brain axis are important targets for treatment of obesity.33 Historically, options for treatment of obesity focused on dietary modification and exercise.34 Many of the comorbidities associated with obesity can be effectively managed with a sustained 510% body weight loss, which is a reasonable first step for most patients.35 Bariatric surgical options, which result in more than 25% total body weight loss, are not widely adopted due to costs and side effect profile.36,37 Fortunately, there has been substantial expansion of pharmacological therapies for obesity in the last decade