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Alcoholism Can GLP-1 Medications Help Treat Alcohol Use Disorder

Initially, main concerns were receptor-activating activity while recently, downstream effects of GLP-1R and GIPR have been more and more revealed that not only receptor activation promotes cAMP and stimulates insulin releasing, but also other factors (-arrestin recruitment, residence time, etc.) influence receptor internalization, which further elicits long-term effects in vivo

Efficacy of GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists in managing MALFD: a meta-analysis of randomized controlled trials

10.1016/j.redox.2023.102849 Redox Biol