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These successes are even more pronounced in those treated with tirzepatide, with nearly 60% of patients losing 20% of their weight and nearly 40% losing even more than 25% of their initial weight (Figure 6B)

[1] [12] Given the growing prevalence of type 2 diabetes and obesity in the United States, tirzepatide has become an important therapeutic option for millions of patients

Clinical trial participants reported the most discomfort when they first started taking tirzepatide, or when they increased their dose

Feb 27, 2026 Tired of stepping on the scale and seeing the number go up, not down, while injecting tirzepatide every week