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Given the low circulating and tissue levels of most DPP-4 substrates and the technical challenge inherent in quantifying intact versus cleaved peptides, it seems likely that some DPP-4 substrates currently classified as pharmacological may one day also be found to be cleaved by DPP-4 in vivo [20]
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Singh S, Wright EE Jr, Kwan AY, Thompson JC, Syed IA, Korol EE, et al
Improper storage can reduce the medicines quality
