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how long have glp 1 drugs been around GLP-1 History: Has This Drug Used? Frontiers | GLP-1 receptor agonists:
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doi: 10.1016/S0140-6736(15)00803-X 36 BendottiGMontefuscoLLunatiMEUsuelliVPastoreILazzaroniEet al

Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

465 Impaired GLP-1 secretion or reduced GLP-1R expression may result in aberrantly heightened sympathetic excitation

The extra-pancreatic effects of GLP-1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems
