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#Article Beyond Weight Loss: Early Real-World Evidence of Semaglutide in Obesity By Stelua Constana Boroghin et al

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Research published in Neuroscience Applied in 2024 demonstrated that semaglutide reduces appetite while simultaneously increasing dopamine reward signalling in the ventral tegmental area a key node in the brain's reward circuitry

a study was conducted over 68 weeks, baseline weight 96kg: - 25mg caused weight loss of 7kg (7.3%) - 14mg caused weight loss of 4.5kg (4.7%) still nowhere near injectable performance, but this shows oral semaglutide has a dose-response curve