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Corrective actions did not yet demonstrate sustainable control Although procedural changes were described, FDA did not see sufficient evidence that the revised system would consistently ensure compliant follow-up in the future
By month 4, GI side effects fade into background noise for 85%+ of patients, leaving appetite suppression as the primary ongoing effect, which is the desired therapeutic response
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Other upregulated antioxidants included perilipin 5 (1.39-fold, p=0.008)), which has been shown to optimize ATP generation efficiency by regulating the oxidation of fatty acids
