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Within the brain, LepR-expressing neurons are distributed in hypothalamus and other brain areas, and each population of the LepR-expressing neurons may mediate particular aspects of leptin effects

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Retatrutide Side Effects (Preliminary Data) Common (from Phase 2 data): Nausea (25-45% depending on dose) Diarrhea (20-35%) Vomiting (10-20%) Constipation (10-15%) Decreased appetite Notable differences: Mild increases in resting heart rate observed The glucagon receptor component may introduce metabolic effects not seen with GLP-1-only medications Full safety profile awaiting Phase 3 data The overall tolerability of retatrutide in the Phase 2 trial was described as acceptable, with most adverse events being mild to moderate