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Macronutrient composition and management of non-insulin-dependent diabetes mellitus (NIDDM): A new paradigm for individualized nutritional therapy in diabetes patients
10.1021/mp500519s
Semaglutide incorporates Aib at position 8 and a C18 fatty diacid chain at (Lys 26 ), conferring DPP-4 resistance and a 165 hours half-life enabling once-weekly dosing [13] Tirzepatide has Aib at the second residue and an acylated lysine (Lys 20 ) with a C18-C20 diacid resulting in a 120-hour half-life and weekly dosing
