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Although prior studies using pre-2020 data indicated that primary care physicians and endocrinologists accounted for approximately 90% of GLP-1 RA prescriptions, with cardiologists representing a smaller proportion, 35 it is unknown whether these prescribing patterns have changed with the increased awareness, broader recognition, and expanded indications of GLP-1 RAs beyond diabetes

Some GLP-1 analogues may influence glutamatergic and GABAergic pathways, potentially contributing to therapeutic effects in conditions such as epilepsy, autism spectrum disorders, and addiction, although further validation is required

Call 999 or go to A&E immediately if you experience: Severe chest pain or breathing difficulties Black, tarry stools or vomit that looks like coffee grounds with dizziness or weaknessthese are signs of significant gastrointestinal bleeding Facial swelling or severe allergic reactions affecting breathing Contact your GP urgently or call NHS 111 if: You experience severe or persistent abdominal pain , which could indicate gastric irritation or other complications You develop severe nausea or vomiting that prevents adequate fluid or food intake You experience signs of dehydration including dark urine, dizziness, reduced urination, or extreme thirst You notice swelling of ankles or legs , which could indicate fluid retention You develop unexplained breathlessness You experience allergic reactions such as rash or itching Before Starting Concurrent Treatment: Inform your prescriber about: All current medications, including over-the-counter products and supplements Any history of stomach ulcers, gastrointestinal bleeding, or kidney problems Previous adverse reactions to NSAIDs or GLP-1 medications Existing cardiovascular conditions Pregnancy, breastfeeding, or plans to conceive (semaglutide should be stopped at least 2 months before planned pregnancy

For healthcare professionals and members of the public reporting suspected adverse reactions to licensed or unlicensed medicines used in routine clinical care (outside of a clinical trial), the MHRA operates the Yellow Card scheme , available at yellowcard.mhra.gov.uk