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Description
Early DPP4is that also blocked DPP8 and DPP9 exhibited severe toxicity in preclinical animal models [64]

Clin Endocrinol (Oxf) 2016;84:115120

But its not the end of the story

In 1980, the intestinal glucagon-like material, glicentin, was identified along with a smaller species named oxyntomodulin in 1982
