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The clinical trials that showed the lowest nausea rates used the slowest titration schedules
However, BBRs translational applications face biopharmaceutical challenges, including poor intestinal absorption ( 50% in obesity across murine and human models [170,171,172,173]
Prebiotics, such as chicory root fiber, serve as food for good bacteria in the gut
However, recent work has challenged this traditional view, because individual enteroendocrine cells have been shown to express multiple gut peptides (1113)
