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If applicable, discuss contraception, as tirzepatide can reduce the exposure to oral contraceptives

The use of more prescriptive meal plans such as meal replacements, especially during the first few months of treatment, has been shown to have a positive benefit in terms of weight reduction in patients with T2DM and should be considered alongside obesity medication where appropriate [109,110]

Interestingly, in our experiments, 10 pmol/L GLP-1 (normal physiological postprandial concentration) suppressed GABA currents (28.11% 12.50% of control) more strongly than 50 nmol/L exendin-4 (69.08% 5.71% of control)

In fact, FDA labeling indicates that no dose adjustment is needed for patients with hepatic impairment