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Domestic pharmaceutical preparation companies that have deployed GLP - 1 innovative drugs and are progressing rapidly also include Huadong Medicine (oral small - molecule HDM1002, dual - target HDM1005, triple - target DR10624), Innovent Biologics (Marsdulotide), Zhongsheng Pharmaceutical (bi - weekly formulation RAY1225), Borui Pharmaceutical (BGM0504), CSPC Pharmaceutical Group (monthly formulation advanced to Phase 1 clinical trials), etc

Furthermore, as for cardiac fibroblasts, GLP-1RAs inhibit Ang II and glucose-induced collagen formation via decreasing phospho-NF-B-p65 and phospho-ERK1/2 expression [169] (Figure 2)

Differences Between Wegovy and Ozempic Ozempic ( semaglutide ) received FDA approval in December 2017, to treat type 2 diabetes in adults

Adlyxin (lixisenatide) This medication for type 2 diabetes is administered via daily injection