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Description
By the late 1970s admissions to hospital and the workload of gastric surgeons had begun to decline as a result of the introduction of H2 receptor agonists, a new class of drugs that block the action of histamine

doi: 10.7759/cureus.25946, 12

So how did we get from GLP-1 for diabetes to GLP-1 for weight loss

This response promotes proper nutrient metabolism by increasing glucose utilization in insulin-dependent tissues such as muscle and adipose tissue, reducing endogenous glucose production, and enhancing glycogen synthesis
