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This includes structured dietary approaches such as portion control, increased protein intake (1.2 to 1.6 grams per kilogram of body weight daily, with caution in chronic kidney disease), and emphasis on whole foods with high satiety value

Interestingly, a rare missense mutation in the GLP1R appears to confer a reduced risk for coronary heart disease development [42]

Liver cancer was defined as primary liver malignancy, including hepatocellular carcinoma, and the term liver cancer is used consistently throughout the manuscript

In rodents, central GLP-1 receptor activation stimulates sympathetic outflow to adipose tissue, induces thermogenic gene programs, and promotes browning of white adipose depots ( In humans, however, BAT mass is limited, heterogeneous, and reduced in obesity, and even maximal activation contributes only modestly to total energy expenditure (31)