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A new randomized clinical trial just published inJAMA Psychiatrytested semaglutide (a GLP-1 agonist) in people with schizophrenia, prediabetes, and obesity who were taking antipsychotics

Among patients with polycystic ovary syndrome (PCOS), the median one-year weight change was an 11.5% loss for those treated with a GLP-1, compared to a 1.9% loss among those treated with metformin.

Although there is no typical user, GLP-1 patients are more likely to be in the Gen X age demographic and come from households with incomes over $100,000.
