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However, the metabolic changes from weight loss, including ketosis and dietary modifications, can indirectly affect urine smell

Preparing the patient for what to expect fosters realistic expectations, builds trust, and encourages adherence to therapy

In a recent double-blind randomized controlled trial, supplementation of A. muciniphilia for three months in obese participants demonstrated improved insulin sensitivity (+28.627.02%, P=0.002), and reduced insulinemia (34.087.12%, P=0.006) compared to placebo [9]. These effect sizes are not only statistically significant, they are also clinically significant and quite impressive for just administration of a single ingredient. This was a proof of concept study and we will update this page as more human literature is published investigating the metabolic effects of A. muciniphilia supplementation