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We anticipate that the focus will shift toward more cost-effective formulations, potentially including oral GLP-1s, and exploring comprehensive treatment approaches that combine medication with lifestyle changes

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Kosinski and colleagues constructed a variant of OXM, OXMQ3E, that was unable to activate the GCGR by changing the third amino acid residue from neutral glutamine to acidic glutamate (38)

However, the discontinuation rates for Danuglipron across different doses were over 50%, significantly higher than the approximately 40% observed in the placebo group, indicating poor tolerability in some patients